|摘要：||Study on The Bioactivity And Cytotoxic Effects of Essential Oils from The Genus Origanum in Human Leukemia.
Chunling Chi1, Yuhsin Chen2, and Huey-Lan Huang3, #,*
1Department of Family Medicine, Sin-Lau Christian Hospital（新樓醫院）, Tainan, Taiwan, ROC
2Taichung District Agricultural Research and Extension Station（台中農改場）, Council of Agriculture, Executive Yuan, Taichung, Taiwan, ROC
3Department of Bioscience Technology, College of Health Science, Chang Jung Christian University（長榮大學）, Tainan, Taiwan, ROC
Origanum genus belongs to the Lamiaceae family. Many Origanum plants with aromatic properties and flavors are important therapeutic, perfume and culinary spice plants, especially for their flowers and leaves. In this study, O. majorana were used to make essential oils, and the cytotoxicity of human leukemia cells was tested. The cytotoxicity test uses morphology observation, trypan blue cell count and MTS cell viability assay. The results showed that O. majorana essential oil at a concentration of 0.125% to 0.25% had high cytotoxicity to chronic leukemia cells K562, and was concentration- and time-dependent. Based on the data of our study, follow-up experiments will be conducted on the killing mechanisms by which components in blood cancer cells. In conclusion, essential oil made from Origanum plants can be used to develop anti-leukemia drugs in the future.