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題名:High Toxicity and Carcinogenesis of Occupational Exposure to 4,4 ’- Methylenebis (2-Chloroaniline) (MBOCA)
作者:Hong-I Chen
期刊名稱:Occupational Medicine & Health Affairs
發表頁數:pp.1000213
發表年份:2015
發表月份:8
摘要:Few studies have been performed on the genotoxicity of MBCOA, and there are literature reports of urinary bladder tumours in dogs exposed to MBOCA. In addition, a recently experimental report showed that pathological changes involved the liver, kidney and urinary bladder of MBOCA treated mice revealed unusual lesions of inflammatory degeneration and malignant change. The plasma 8-hydroxydeoxyguanosine (8- OHdG) levels showed that the MBOCA-treated mice had significantly higher 8-OHdG levels than the control mice [12]. Those results support the conclusion that MBOCA is a carcinogen and highly toxic to both animals and humans.
關鍵字:
英文關鍵字:4,4’-Methylenebis (2-chloroaniline); MBOCA; Transitional cell carcinoma of bladder; Oxidative DNA damage; 8-Hydroxydeoxyguanosine
DOI:10.4172/2329-6879
Vol:3
NO:4
ISSN: 2329-6879
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