Responsive image

 首頁 |   Language  : English

因學術研究等數據庫資料龐大,搜尋與運算需花費5至10秒,請您稍侯.

健康科學學院 > 醫學研究所 > 期刊論文 >


題名:Amino-Functionalized Nitrogen-Doped Graphene Quantum Dots for Efficient Enhancement of Two-Photon-Excitation Photodynamic Therapy:Functionalized Nitrogen as a Bactericidal and Contrast Agent
作者:Wen-Shuo Kuo, Tien-Sung Yeh , Chia-Yuan Chang, Jui-Chang Liu, Chang-Hsin Chen, Edmund Cheung So, Ping-Ching Wu
期刊名稱: International Journal of Nanomedicine.
發表頁數:6961–6973
發表年份:2020
發表月份:9
摘要:Background: Although graphene quantum dots (GQDs) have received considerable research attention for their applications in various fields, the use of GQDs, such as nitrogen- doped GQDs (N-GQDs) and amino-functionalized N-GQDs (amino-N-GQDs), as photosensitizers to facilitate photodynamic therapy (PDT) has received limited research intention. To address this research gap, this study prepared novel amino-N-GQDs and investigated their properties. Methods: The amino-N-GQDs subjected to two-photon excitation (TPE) exhibited remarkable bactericidal capability in PDT. The bonding compositions of nitrogen and the aminofunctionalized group played a critical role in their antimicrobial effects. Results: Compared with amino-group-free N-GQDs and amino-N-free GQDs, the amino-NGQDs generated a higher amount of reactive oxygen species, demonstrating their superior efficacy for two-photon PDT. Additionally, the intrinsic luminescence properties and high photostability of the amino-N-GQDs demonstrate their suitability as an effective two-photon contrast agent for tracking bacteria during two-photon biomedical imaging. Conclusion: The amino-N-GQD and their remarkable properties may provide an efficient alternative approach for observing and easily eliminating malignant microbes in the future. Keywords: nitrogen atom-doped graphene quantum dots, amino-functionalized and nitrogen atom-doped graphene quantum dots, two-photon photodynamic therapy, two-photon contrast agent, two-photon biomedical imaging
關鍵字:
英文關鍵字:nitrogen atom-doped graphene quantum dots, amino-functionalized and nitrogen atom-doped graphene quantum dots, two-photon photodynamic therapy, two-photon contrast agent, two-photon biomedical imaging
DOI:http://doi.org/10.2147/IJN.S242892
NO:15
ISSN:11782013, 11769114
全文下載:下載