|題名：||Amino-Functionalized Nitrogen-Doped Graphene Quantum Dots for Efficient Enhancement of Two-Photon-Excitation Photodynamic Therapy:Functionalized Nitrogen as a Bactericidal and Contrast Agent|
|作者：||Wen-Shuo Kuo, Tien-Sung Yeh , Chia-Yuan Chang, Jui-Chang Liu, Chang-Hsin Chen, Edmund Cheung So, Ping-Ching Wu|
|期刊名稱：|| International Journal of Nanomedicine.|
|摘要：||Background: Although graphene quantum dots (GQDs) have received considerable
research attention for their applications in various fields, the use of GQDs, such as nitrogen-
doped GQDs (N-GQDs) and amino-functionalized N-GQDs (amino-N-GQDs), as
photosensitizers to facilitate photodynamic therapy (PDT) has received limited research
intention. To address this research gap, this study prepared novel amino-N-GQDs and
investigated their properties.
Methods: The amino-N-GQDs subjected to two-photon excitation (TPE) exhibited remarkable
bactericidal capability in PDT. The bonding compositions of nitrogen and the aminofunctionalized
group played a critical role in their antimicrobial effects.
Results: Compared with amino-group-free N-GQDs and amino-N-free GQDs, the amino-NGQDs
generated a higher amount of reactive oxygen species, demonstrating their superior
efficacy for two-photon PDT. Additionally, the intrinsic luminescence properties and high
photostability of the amino-N-GQDs demonstrate their suitability as an effective two-photon
contrast agent for tracking bacteria during two-photon biomedical imaging.
Conclusion: The amino-N-GQD and their remarkable properties may provide an efficient
alternative approach for observing and easily eliminating malignant microbes in the future.
Keywords: nitrogen atom-doped graphene quantum dots, amino-functionalized and nitrogen
atom-doped graphene quantum dots, two-photon photodynamic therapy, two-photon contrast
agent, two-photon biomedical imaging|
|英文關鍵字：||nitrogen atom-doped graphene quantum dots, amino-functionalized and nitrogen atom-doped graphene quantum dots, two-photon photodynamic therapy, two-photon contrast agent, two-photon biomedical imaging|