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健康科學學院 > 醫學研究所 > 期刊論文 >

題名:Differential mechanisms of synaptic plasticity for susceptibility and resilience to chronic social defeat stress in male mice
作者:Chi-WeiLee, Yen-PoFang, Ming-Chia, Chu, Yueh-JungChung, HsiangChia, Chih-WeiTang, Edmund CheungSo, Hsin-ChuanLin, Hui-ChingLin
期刊名稱:Biochemical and Biophysical Research Communications
摘要:Mood dysregulation refers to the inability of a person to control their negative emotions, and it is linked to various stressful experiences. Dysregulated neural synaptic plasticity and actin-filament dynamics are important regulators of stress response in animal models. However, until now, there is no evidence to differential the mechanisms of synaptic plasticity and actin-filament dynamics in stress susceptibility and stress-resistant. Here we found that depression-like behaviour was observed in the susceptible group following chronic social defeat stress (CSDS) exposure, but not in stress-resistant mice. High-frequency stimulation-induced long-term potentiation (LTP) was impaired in the CSDS-induced depression-susceptible group. Further, the levels of pro-brain derived neurotrophic factor (BDNF), mature BDNF, PSD-95, phosphorylated CaMKII, and phosphorylated Cofilin, an actin-filament dynamics regulator, were reduced in CSDS-induced depression-susceptible mice unlike in stress-resistant mice. These results demonstrate that synaptic plasticity-related molecules, such as BDNF and phosphorylated Cofilin, are important for maintaining synaptic functions and structure in mice that experience more stress.
英文關鍵字:Brain derived neurotrophic factor; Chronic social defeat; Cofilin; Long-term potentiation; Stress.
DOI: 10.1016/j.bbrc.2021.05.064
Vol:Vol 562